Translational Science Sarcoidosis, alveolar b-actin and pulmonary fibrosis
نویسندگان
چکیده
G. COOKE, P. GOVENDER, C.J. WATSON, M.E. ARMSTRONG, D.N. O’DWYER, M.P. KEANE, R. KING, A. TYNAN, M. DUNN* and S.C. DONNELLY* From the School of Medicine and Medical Science, Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland, Medicine & Therapeutics, St. Vincent’s University Hospital, Crumlin, Dublin 12, Ireland and Our Lady’s Children’s Hospital, Crumlin, Dublin 12, Ireland
منابع مشابه
Thalidomide reduces IL-18, IL-8 and TNF-alpha release from alveolar macrophages in interstitial lung disease.
Thalidomide exhibits diverse actions of anti-inflammation, immunomodulation and anti-angiogenesis. The efficacy of thalidomide treatment in sarcoidosis with lupus pernio is thought to be due to inhibition of tumour necrosis factor (TNF)-alpha. The mechanisms that underlie the properties of thalidomide are still unclear in interstitial lung disease. The current authors investigated the potential...
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BACKGROUND Fractional exhaled nitric oxide (FeNO) is a non-invasive biomarker of airway inflammation and nitrosative stress. Previous studies have suggested a possible role of FeNO in the management of patients with pulmonary sarcoidosis, but published data are discordant. OBJECTIVES To assess the clinical usefulness of FeNO and alveolar concentration of NO (CalvNO) in sarcoidosis. METHODS ...
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Introduction: A case of pulmonary sarcoidosis is reported because of difficulties in diagnosis and treatment, including the co-existence of ankylosing spondylitis (AS) and severe corticosteroid dependence. Case Presentation: A 48-year-old nonsmoking woman referred to the hospital because of chronic nonproductive cough and dyspnea with a 10-year history of...
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Haem oxygenase (HO)-1 is an oxidative stress responsive protein that may be involved in the pathogenesis of interstitial lung disease. HO-1 expression in alveolar macrophages from bronchoalveolar lavage was investigated in 24 patients with idiopathic pulmonary fibrosis (IPF), 16 with sarcoidosis, 14 with hypersensitivity pneumonitis (HP) and 13 controls. Using immunocytochemistry, HO-1 expressi...
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Alveolar macrophages (AMs) from patients with interstitial lung diseases, such as sarcoidosis and idiopathic pulmonary fibrosis, suppress the phytohaemagglutinin (PHA) stimulation of autologous peripheral lymphocytes. The aim of this study was to determine whether the suppressive effect of alveolar macrophages of patients with interstitial lung disease is due, not only to the secretion of solub...
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